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 Shandong Haohong Biotechnology Co., Ltd.

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HomeProductsActive Pharmaceutical Ingredient(API)Apalutamide APIApalutamide API Cas 956104-40-8

Apalutamide API Cas 956104-40-8

Payment Type:
L/C,T/T,Paypal,Western Union
Min. Order:
1 Kilogram
Delivery Time:
3 Days
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  • Product Description
Product Attributes

Model No.Cas 956104-40-8


place of originChina

Types ofPharmaceutical Intermediates

Phasical StateSolid Powder




ColorOff White

CAS No.956104-40-8

Molecular FormulaC21H15F4N5O2S

Molecular Weight477.43500



Supply Ability & Additional Informations

PackagingPE BAG+Aluminum foil bag+FIBRE DRUM




Supply Ability1MT/MONTH

HS Code2933990090


Payment TypeL/C,T/T,Paypal,Western Union


Delivery Time3 Days

Packaging & Delivery
Selling Units:
Package Type:
PE BAG+Aluminum foil bag+FIBRE DRUM

Apalutamide (INN) (developmental code name ARN-509, also JNJ-56021927) is a non-steroidal antiandrogen that is under development for the treatment of prostate cancer. It is similar to enzalutamide both structurally and pharmacologically, acting as a selective competitive antagonist of the androgen receptor (AR), but shows some advantages, including greater potency and reduced central nervous system permeation. Apalutamide binds weakly to the GABAA receptor similarly to enzalutamide, but due to its relatively lower central concentrations, may have a lower risk of seizures in comparison.
The drug has been found to be effective and well-tolerated in clinical trials thus far, with the most common side effects reported including fatigue, nausea, abdominal pain, and diarrhea.
Apalutamide is currently in phase III clinical trials for castration-resistant prostate cancer.
Recently, the acquired F876L mutation of the AR identified in advanced prostate cancer cells was found to confer resistance to both enzalutamide and apalutamide. A newer antiandrogen, darolutamide (ODM-201), is not affected by this mutation, nor has it been found to be affected by any other tested/well-known AR mutations.; Apalutamide may be effective in a subset of prostate cancer patients with acquired resistance to abiraterone acetate.


QCR-211;4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide;ARN 509;Benzamide,4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methyl;4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide;N-methyl-4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide;4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro(3.4)octan-5-yl)-2-fluoro-N-methylbenzamide;ARN-509;


Erleada ®;A52;

We, Shandong Haohong Biotechnology Co., Ltd. are manufacture of API and intermediates, Apalutamide is our top strong project.

API name: APALUTAMIDE CAS No.: 956104-40-8

We can offer best quality product with perfect service, full documents support, factory audit is available.

Purity HPLC:> 99%

Water contents :< 0.50%

Packing and Storage: Preserve in well-closed containers, and store at room temperature.

Apalutamide Cas 956104-40-8

Our Apalutamide & Enzalutamide Intermediate list is as following, we have all the below intermediates offering all year.



Apalutamide APIApalutamide Cas 956104-40-8

Apalutamide IntermediatesApalutamide Cas 915087-25-1Apalutamide Cas 403-24-7

Apalutamide Intermediates 573762-62-6;Apalutamide Cas 951753-87-0

Apalutamice INN ARN-509

Package & Shipping:

1. Preferentially DHL or FedEx for quantity less than 50KG; Air shipping for 100KG above; Sea shipping for quantity over 500KG.
2. We can offer complete package from concept to delivery; arranging everything up until products arrive at your own door or distribution hub.


Our Service:

1. Supply high quality products with reasonable prices for pharmaceutical factory.
2. In time delivery, Packing pictures and loading video before loading.
3. Various documents(COA, MSDS, ROS, MOA etc.) and factory audit available.
4. Pre-sale consultation and post-sale service available.
5. Provide market informations to make customers fully informed.

Product Categories : Active Pharmaceutical Ingredient(API) > Apalutamide API

Company Overview
Shandong Haohong Biotechnology Co., Ltd. is located in Provincial Chemical Industrial Park of Liaocheng city, Shandong province, which is a beautiful water city. The total production area is around 130 thousand square meters, with 40 employees and 12 R&D technicians. Our company focuses on the development and production of pharmaceutical products, with 13 sets of 50L to 5000L reactors, and the annual manufacturing capacity can up to 500 tons. We had advanced sewage treatment system, with the daily processing capacity of 1000 tons. The new R&D laboratory is located on the 4th floor of the accelerator middle section of Qilu Science and Technology Town, Qilu High-tech Development Zone, Shandong Province, and is located in a large modern ecological science and technology park in Qihe Science and Technology City of Zhongguancun Haidian Park. Our company mainly focuses on the development of anti-cancer, anti-diabets series of API and its advanced intermediates. The main products include Bicalutamide, enzalutamide, apalutamide, macitentan, cabozantinib, ceritinib, empagliflozin, tofacitinib citrate, and alectinib,etc. In line with the concept of "truth-seeking, innovation and integrity", we had exported our products to the United States, European countries, Japan, India, Bangladesh and other overseas markets. At present, Our company has dozens of advanced intermediates, all of which are commercialized, and at the same time, we can provide customers with efficient customized synthesis services from grams to 100 kilograms. We will continue to provide high quality products with most competitive prices and good service to customers all over the world. We sincerely hope to establish stable and strategic business relationships with customers from home and abroad.
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