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 Shandong Haohong Biotechnology Co., Ltd.

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HomeProductsAnti-cancer DrugGilteritinib Intermediates

Gilteritinib Intermediates (Total 5 Products)

Product categories of Gilteritinib Intermediates, we are specialized manufacturers from China, Gilteritinib Cas 1254058-34-8, Gilteritinib Cas 2043020-03-5 suppliers/factory, wholesale high-quality products of Gilteritinib Cas 454-16-0 R & D and manufacturing, we have the perfect after-sales service and technical support. Look forward to your cooperation!
Pharmaceutical Raw Material Cas 1254058-34-8

Brand: HAOHONG

Packaging: PE BAG+Aluminum foil bag+FIBRE DRUM

Supply Ability: 30MT/MONTH

Product Name 3 methoxy 4 4 4 methylpiperazin 1 yl piperidin 1 yl aniline 3 methoxy 4 4 4 methyl 1 piperazinyl 1 piperidinyl benzenChemicalbookamine Benzenamine 3 methoxy 4 4 4 methyl 1 piperazinyl 1 piperidinyl API name Gilteritinib Intermediate CAS...
Gilteritinib Intermediate Cas 1254058-34-8

Brand: HAOHONG

Packaging: PE BAG+Aluminum foil bag+FIBRE DRUM

Supply Ability: 30MT/MONTH

Product Name 3 methoxy 4 4 4 methylpiperazin 1 yl piperidin 1 yl aniline 3 methoxy 4 4 4 methyl 1 piperazinyl 1 piperidinyl benzenChemicalbookamine Benzenamine 3 methoxy 4 4 4 methyl 1 piperazinyl 1 piperidinyl API name Gilteritinib Intermediate CAS...
Gilteritinib Intermediate Cas 2043020-03-5

Brand: HAOHONG

Packaging: PE BAG+Aluminum foil bag+FIBRE DRUM

Supply Ability: 30MT/MONTH

Product Name 3 bromo 5 chloro 6 ethylpyrazine 2 carbonitrile 2 Pyrazinecarbonitrile 3 bromo 5 chloro 6 ethyl API name Gilteritinib Intermediate CAS No 2043020 03 5 We Shandong Haohong Biotechnology Co Ltd are manufacture of API and intermediates...
Gilteritinib Intermediate Cas 454-16-0

Brand: HAOHONG

Packaging: PE BAG+Aluminum foil bag+FIBRE DRUM

Supply Ability: 30MT/MONTH

Product Name 2 Fluoro 5 Nitroanisole 1 Fluoro 2 methoxy 4 nitrobenzene API name Gilteritinib Intermediate CAS No 454 16 0 We Shandong Haohong Biotechnology Co Ltd are manufacture of API and intermediates Gilteritinib is our top strong project...
Gilteritinib Intermediate Cas 33024-60-1

Brand: HAOHONG

Packaging: PE BAG+Aluminum foil bag+FIBRE DRUM

Supply Ability: 30MT/MONTH

Product Name 4 Aminotetrahydropyran hydrochloride tetrahydro 2H pyran 4 ylamine hydrochloride tetrahydro 2H pyran 4 ylamine monohydrochloride 4 AMINOTETRAHYDRO 4H PYRAN HYDROCHLORIDE 4 Aminotetrahydro 2H pyran hydrochloride TETRAHYDRO PYRAN 4...

China Gilteritinib Intermediates Suppliers

Gilteritinib is an orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) FMS-related tyrosine kinase 3 (FLT3, STK1, or FLK2), AXL (UFO or JTK11) and anaplastic lymphoma kinase (ALK or CD246), with potential antineoplastic activity. Gilteritinib binds to and inhibits both the wild-type and mutated forms of FLT3, AXL and ALK. This may result in an inhibition of FLT3, AXL, and ALK-mediated signal transduction pathways and reduces tumor cell proliferation in cancer cell types that overexpress these RTKs. FLT3, AXL and ALK, overexpressed or mutated in a variety of cancer cell types, play a key role in tumor cell growth and survival.

Gilteritinib is an orally available small molecule inhibitor of FMS-like tyrosine kinase 3 (FLT3) which is used as an antineoplastic agent in the treatment of acute myeloid leukemia with FLT3 mutations. Gilteritinib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.

Gilteritinib is a member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation. It has a role as an apoptosis inducer, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an antineoplastic agent. It is a N-methylpiperazine, a member of piperidines, a secondary amino compound, a monomethoxybenzene, a member of pyrazines, a primary carboxamide, an aromatic amine and a member of oxanes.

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