Macitentan API cas 441798-33-0,Macitentan Intermediate 146533-41-7,Macitentan Intermediate 706811-25-8,Macitentan Intermediate 147962-41-2 Manufacturers and Suppliers in China

China Macitentan API And Intermediates Suppliers

Macitentan is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents ET-1 mediated signaling transduction which may decrease tumor cell proliferation, progression, and angiogenesis in tumor tissue. ET-1, a potent vasoconstrictor that plays an important role in inflammation and tissue repair, is, together with its receptors, overexpressed varyingly in many tumor cell types.

Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). Macitentan has been associated with a low rate of serum enzyme elevations during therapy, but has yet to be implicated in cases of clinically apparent acute liver injury.

Macitentan is a member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an endothelin receptor antagonist, an antihypertensive agent and an orphan drug. It is an organobromine compound, a member of pyrimidines, an aromatic ether, a ring assembly and a member of sulfamides. It derives from an ethylene glycol and an ACT-132577.

China Macitentan API cas 441798-33-0,Macitentan Intermediate 146533-41-7,Macitentan Intermediate 706811-25-8,Macitentan Intermediate 147962-41-2,Macitentan Intermediate 1393813-41-6, we offered that you can trust. Welcome to do business with us.

Min.Order	Unit Price
1 Kilogram	USD 1 / Kilogram

Min.Order	Unit Price
1 Kilogram	USD 1 / Kilogram

Min.Order	Unit Price
1 Kilogram	USD 1 / Kilogram

Min.Order	Unit Price
1 Kilogram	USD 1 / Kilogram

Min.Order	Unit Price
1 Kilogram	USD 1 / Kilogram

Macitentan API And Intermediates

Good stock Macitentan Intermediate Cas 1642873-03-7

Good stock Macitentan API Cas 441798-33-0

Good stock Macitentan Cas 1393813-42-7

Commercilized Propylsulfamide potassium Cas 1393813-41-6

Good stock Macitentan Cas 147962-41-2

Good Stock Macitentan Intermediate Cas 706811-25-8

Commercilized Macitentan Intermediate Cas 146533-41-7