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 Shandong Haohong Biotechnology Co., Ltd.

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PAH Drugs

China Pah Drugs In Development,Actelion Pah Drugs manufacturer, choose the high quality Macitentan Intermediates CAS 146533-41-7, Macitentan Intermediate Cas 706811-25-8,Macitentan Intermediate Cas 147962-41-2,Macitentan Intermediate Cas 1393813-41-6,Macitentan Intermediate Cas 1393813-42-7,Macitentan Intermediate Cas 1642873-03-7,etc.

Macitentan (trade name Opsumit) is an endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH). The other two ERAs marketed as of 2014 are bosentan and ambrisentan. Macitentan is a dual ERA, meaning that it acts as an antagonist of two endothelin (ET) receptor subtypes, ETA and ETB. However, macitentan has a 50-fold increased selectivity for the ETA subtype compared to the ETB subtype. The drug received approval from the U.S. Food and Drug Administration (FDA) on October 13, 2013.

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