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HomeProductsActive Pharmaceutical Ingredient(API)Gilteritinib API

Gilteritinib API (Total 4 Products)

Product categories of Gilteritinib API, we are specialized manufacturers from China, Gilteritinib Api, Gilteritinib Cas 1254053-43-4 suppliers/factory, wholesale high-quality products of Gilteritinib Asp2215 2 Pyrazinecarboxamide R & D and manufacturing, we have the perfect after-sales service and technical support. Look forward to your cooperation!
Best price Gilteritinib API Offering

Brand: HAOHONG

Packaging: PE BAG+Aluminum foil bag+FIBRE DRUM

Supply Ability: 30MT/MONTH

Product Name ASP2215 Gilteritinib Gilteritinib 2 Pyrazinecarboxamide 6 ethyl 3 3 methoxy 4 4 4 methyl 1 piperazinyl 1 piperidinyl phenyl amino 5 tetrahydro 2H pyran 4 yl amino 6 Ethyl 3 3 methoxy 4 4 4 methyl 1 piperazinyl 1 piperidinyl phenyl amino...
Pharmaceutical Raw Material Cas 1254053-43-4

Brand: HAOHONG

Packaging: PE BAG+Aluminum foil bag+FIBRE DRUM

Supply Ability: 30MT/MONTH

Product Name ASP2215 Gilteritinib Gilteritinib 2 Pyrazinecarboxamide 6 ethyl 3 3 methoxy 4 4 4 methyl 1 piperazinyl 1 piperidinyl phenyl amino 5 tetrahydro 2H pyran 4 yl amino 6 Ethyl 3 3 methoxy 4 4 4 methyl 1 piperazinyl 1 piperidinyl phenyl amino...
Pharmaceutical Raw Material Gilteritinib API

Brand: HAOHONG

Packaging: PE BAG+Aluminum foil bag+FIBRE DRUM

Supply Ability: 30MT/MONTH

Product Name ASP2215 Gilteritinib Gilteritinib 2 Pyrazinecarboxamide 6 ethyl 3 3 methoxy 4 4 4 methyl 1 piperazinyl 1 piperidinyl phenyl amino 5 tetrahydro 2H pyran 4 yl amino 6 Ethyl 3 3 methoxy 4 4 4 methyl 1 piperazinyl 1 piperidinyl phenyl amino...
Gilteritinib API Cas 1254053-43-4

Brand: HAOHONG

Packaging: PE BAG+Aluminum foil bag+FIBRE DRUM

Supply Ability: 30MT/MONTH

Product Name ASP2215 Gilteritinib Gilteritinib 2 Pyrazinecarboxamide 6 ethyl 3 3 methoxy 4 4 4 methyl 1 piperazinyl 1 piperidinyl phenyl amino 5 tetrahydro 2H pyran 4 yl amino 6 Ethyl 3 3 methoxy 4 4 4 methyl 1 piperazinyl 1 piperidinyl phenyl amino...

China Gilteritinib API Suppliers

Gilteritinib is an orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) FMS-related tyrosine kinase 3 (FLT3, STK1, or FLK2), AXL (UFO or JTK11) and anaplastic lymphoma kinase (ALK or CD246), with potential antineoplastic activity. Gilteritinib binds to and inhibits both the wild-type and mutated forms of FLT3, AXL and ALK. This may result in an inhibition of FLT3, AXL, and ALK-mediated signal transduction pathways and reduces tumor cell proliferation in cancer cell types that overexpress these RTKs. FLT3, AXL and ALK, overexpressed or mutated in a variety of cancer cell types, play a key role in tumor cell growth and survival.

Gilteritinib is an orally available small molecule inhibitor of FMS-like tyrosine kinase 3 (FLT3) which is used as an antineoplastic agent in the treatment of acute myeloid leukemia with FLT3 mutations. Gilteritinib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.

Gilteritinib is a member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation. It has a role as an apoptosis inducer, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an antineoplastic agent. It is a N-methylpiperazine, a member of piperidines, a secondary amino compound, a monomethoxybenzene, a member of pyrazines, a primary carboxamide, an aromatic amine and a member of oxanes.

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