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Larotrectinib is an orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival.

Loxo-101 is also known as Larotrectinib. Larotrectinib (LOXO-101) received FDA approval in 2018 for the treatment of adults and children with locally advanced or metastatic solid tumors with NTRK gene fusion. LOXO 101, an anti-tumor drug targeting tropomyosinrelatedkinase (TRK), was approved by the U.S. Food and Drug Administration (FDA) on November 26, 2018 in capsule and oral form. For the treatment of locally advanced or metastatic solid Chemicalbook body tumors in adults and children with NTRK gene fusion, regardless of tumor site. LOXO's LOXO-101 (Larotrectinib) was the highlight of the ASCO conference in 2017. The clinical efficacy of LOXO-101 really caught the attention of many people because the 35-employee company developed Larotrectinib as a surprisingly effective anti-tumor drug. Loxo-101 targets the TRK gene and is effective against 17 types of cancer in adults or children with locally advanced or metastatic tumors, including colon, lung, pancreas, thyroid, saliva and gastrointestinal cancers, with an overall response rate of 75 percent. Loxo-101 is the targeted drug version of PD-1.

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