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HomeProductsAnti-cancer DrugRucaparib Intermediates
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Rucaparib Intermediates

(Total 2 Products)
Rucaparib Intermediate Cas 78902-09-7

Brand: HAOHONG

Packaging: PE BAG+Aluminum foil bag+FIBRE DRUM

Supply Ability: 30MT/MONTH

Product Name: PHTHALIMIDOACETALDEHYDE DIETHYL ACETAL; phthalimido-acetaldehyde hydrate; phthalimidoacetaldehyde diethylacetal; N-phthalimido aminoacetaldehyde diethyl acetal; 2-(2,2-diethoxyethyl)isoindoline-1,3-dione; 2-Phthalimidylacetaldehyde...
Rucaparib Intermediate Cas 2913-97-5

Brand: HAOHONG

Packaging: PE BAG+Aluminum foil bag+FIBRE DRUM

Supply Ability: 30MT/MONTH

Product Name: 2-(1,3-dioxoisoindol-2-yl)acetaldehyde; N-Phthalylaminoacetaldehyde; Phthalimidoacetaldehyde; (1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-ACETALDEHYDE; Phthalylglycine aldehyde; 1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetaldehyde API name:...
Home > Products > Anti-cancer Drug > Rucaparib Intermediates

China Rucaparib Intermediates Suppliers

Rucaparib is an orally bioavailable tricyclic indole and inhibitor of poly(ADP-ribose) polymerases (PARPs) 1 (PARP1), 2 (PARP2) and 3 (PARP3), with potential chemo/radiosensitizing and antineoplastic activities. Upon administration, rucaparib selectively binds to PARP1, 2 and 3 and inhibits PARP-mediated DNA repair. This enhances the accumulation of DNA strand breaks, promotes genomic instability and induces cell cycle arrest and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARPs are enzymes activated by single-strand DNA breaks that catalyze the post-translational ADP-ribosylation of nuclear proteins, which induces signaling and the recruitment of other proteins to repair damaged DNA. The PARP-mediated repair pathway plays a key role in DNA repair and is dysregulated in a variety of cancer cell types.

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