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Model No.: CAS 956104-40-8
Brand: HAOHONG
Place Of Origin: China
Types Of: Pharmaceutical Intermediates
Phasical State: Solid Powder
Purity: 99%
Density: 1.49
Type: Api
Color: Off White
CAS No.: 956104-40-8
Molecular Formula: C21h15f4n5o2s
Molecular Weight: 477.43500
PSA: 121.42000
LOGP: 4.05248
Packaging: PE BAG+Aluminum foil bag+FIBRE DRUM
Productivity: 10MT/YEAR
Transportation: Ocean,Air
Place of Origin: SHANDONG,CHINA
Supply Ability: 1MT/MONTH
HS Code: 2933990090
Port: NANJING PORT,SHANGHAI PORT,BEIJING PORT
Payment Type: L/C,T/T,Paypal,Western Union
Incoterm: FOB,CIF,CPT,CIP
Apalutamide (INN) (developmental code name ARN-509, also JNJ-56021927) is a non-steroidal antiandrogen that is under development for the treatment of prostate cancer. It is similar to enzalutamide both structurally and pharmacologically, acting as a selective competitive antagonist of the androgen receptor (AR), but shows some advantages, including greater potency and reduced central nervous system permeation. Apalutamide binds weakly to the GABAA receptor similarly to enzalutamide, but due to its relatively lower central concentrations, may have a lower risk of seizures in comparison.
The drug has been found to be effective and well-tolerated in clinical trials thus far, with the most common side effects reported including fatigue, nausea, abdominal pain, and diarrhea.
Apalutamide is currently in phase III clinical trials for castration-resistant prostate cancer.
Recently, the acquired F876L mutation of the AR identified in advanced prostate cancer cells was found to confer resistance to both enzalutamide and apalutamide. A newer antiandrogen, darolutamide (ODM-201), is not affected by this mutation, nor has it been found to be affected by any other tested/well-known AR mutations.; Apalutamide may be effective in a subset of prostate cancer patients with acquired resistance to abiraterone acetate.
PRODUCT NAME:
QCR-211;4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide;ARN 509;Benzamide,4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methyl;4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide;N-methyl-4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide;4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro(3.4)octan-5-yl)-2-fluoro-N-methylbenzamide;ARN-509;
JNJ-56021927;JNJ-927;4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide;
Erleada ®;A52;
We, Shandong Haohong Biotechnology Co., Ltd. are manufacture of API and intermediates, Apalutamide is our top strong project.
API name: APALUTAMIDE CAS No.: 956104-40-8
We can offer best quality product with perfect service, full documents support, factory audit is available.
Purity HPLC:> 99%
Water contents :< 0.50%
Packing and Storage: Preserve in well-closed containers, and store at room temperature.
Our Apalutamide & Enzalutamide Intermediate list is as following, we have all the below intermediates offering all year.
Apalutamide API:Apalutamide Cas 956104-40-8
Apalutamide Intermediates:Apalutamide Cas 915087-25-1;Apalutamide Cas 403-24-7;
Apalutamide Intermediates 573762-62-6;Apalutamide Cas 951753-87-0
Package & Shipping:
1. Preferentially DHL or FedEx for quantity less than 50KG; Air shipping for 100KG above; Sea shipping for quantity over 500KG.
2. We can offer complete package from concept to delivery; arranging everything up until products arrive at your own door or distribution hub.
Our Service:
1. Supply high quality products with reasonable prices for pharmaceutical factory.
2. In time delivery, Packing pictures and loading video before loading.
3. Various documents(COA, MSDS, ROS, MOA etc.) and factory audit available.
4. Pre-sale consultation and post-sale service available.
5. Provide market informations to make customers fully informed.
Product Categories : Active Pharmaceutical Ingredient(API) > Apalutamide API
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Privacy statement: Your privacy is very important to Us. Our company promises not to disclose your personal information to any external company with out your explicit permission.